SAMHD1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1-2µg/ml. IHC starting at 5µg/mL. IF start at 20µg/mL.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	SAMHD1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human SAMHD1.
Formulation	SAMHD1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	SAMHD1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 65, 69 kDa; Observed: 62 kDa
Gene Name	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Database Link	NP_056289 Entrez Gene 25939 Human UniProt ID Q9Y3Z3
Background	The SAM domain and HD domain 1 (SAMHD1) protein is upregulated in response to viral infection and is thought to play a role in innate immunity (1). SAMHD1 blocks the infection of HIV-1 and SIVdeltaVpx before reverse transcription in macrophages and dendritic cells (2), and this restriction is regulated by phosphorylation of SAMHD1 (3). Mutations in this gene have been associated with Aicardi-Goutieres syndrome (1).
Synonyms	AGS5; DCIP; HDDC1; Mg11; MOP-5; MOP5; SBBI88
Note	SAMHD1 antibody can be used for detection of SAMHD1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Reference Data

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