STAT3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Dot, WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA N/A IP 2-5 µg/ml IHC 2-10 µg/ml FC Not tested
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide surrounding to the epitope -PMSPR-- with phosphorylation sites at Ser727 of STAT3 protein from human, mouse, rat, chicken dog and bovine origins.
Formulation	This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	94 kDa
Gene Name	signal transducer and activator of transcription 3
Database Link	NP_003141 Entrez Gene 20848 MouseEntrez Gene 25125 RatEntrez Gene 6774 Human UniProt ID P40763
Background	STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a lignad binding to its cell surface receptor. The phosphorylation of STAT3 induces STAT dimerization, nuclear translocation and DNA binding. Stat3 is constitutively activated in a number of human tumors. Stat3-activated transcription seems to be regulated by serine phosphorylation at Ser727.
Synonyms	ADMIO; APRF; HIES
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Acute myeloid leukemia, Adipocytokine signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.