LYRIC (MTDH) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat, Bovine
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from the c-term of human AEG1. This sequence is identical to human, mouse, rat and bovine
Formulation	This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	64 kDa
Gene Name	metadherin
Database Link	NP_848927 Entrez Gene 67154 MouseEntrez Gene 170910 RatEntrez Gene 92140 Human UniProt ID Q86UE4
Background	AEG1 (Astrocyte elevated gene 1), also called Metadherin (MTDH), or L LYsine-RIch CEACAM1 co-isolated (LYRIC), is 582 aa single transmembrane domain (TMD) protein, this protein is widely expressed and highly conserved between species. It is not a structural component for tight junctional (TJ) complexes, it is recruited during the maturation of the tight junction complex and co-localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells. This novel protein is also reported as an HIV-1 inducible gene, which is expressed ubiquitously with higher expression in tissues containing muscular actin and its expression is increased in astrocytes infected with HIV-1 or treated with gp120 or tumor necrosis factor (TNF)-alpha. AEG1 expression is elevated in subsets of breast carcinomas, malignant gliomas and melanomas. AEG1 may affect tumor progression in multiple cell lineages by augmenting expression of the transformed phenotype and/or by inducing glutamate excitotoxicity in malignant glioma. In these contexts, an HIV-1-inducible gene, AEG-1, may contribute to multiple brain abnormalities and tumor formation, by both common and distinct mechanisms.
Synonyms	3D3; AEG-1; AEG1; LYRIC
Reference Data
Protein Families	Transmembrane

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