MMP13 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the hinge of human MMP13 protein. This sequence is identical among the human, mouse and rat origins.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60 kDa, 48 kDa
Gene Name	matrix metallopeptidase 13
Database Link	NP_002418 Entrez Gene 4322 Human UniProt ID P45452
Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Unpaired specific MMPs by tissue inhibitor of MMPs (TIMPs) are related in the invasive tumor processes. Interstitial collagenase (MMP-1)(52 kDa), gelatinase A/type IV collagenase (MMP-2) (72 kDa), and gelatinase B/type V collagenase (MMP-9) (92 kDa) dissolve extracellular matrix (ECM) and may initiate and promote angiogenesis. Human collagenase-3 (MMP13) is a recently identified member of the matrix metalloproteinase (MMP) family that is expressed in breast carcinomas and in articular cartilage from arthritic patients. This protein is secreted as a 60 kDa proenzyme and active form of 48 kDa by cleavage.
Synonyms	CLG3; MANDP1; MDST; MMP-13
Reference Data
Protein Families	Druggable Genome, Protease

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