Factor VIII (F8) Rabbit Polyclonal Antibody

CAT#: TA354646

Rabbit anti Coagulation Factor VIII (Cleaved form, N-term) Polyclonal Antibody



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CNY 4,675.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Recommend Dilution WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide corresponding to N-term of the cleavage form VLLKRHHQR of human FVIII protein. It also identical to mouse, chicken origin.
Formulation This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 185 kDa, 265 kDa
Gene Name coagulation factor VIII
Background The Coagulation Factor VIII (FVIII) is a glycoprotein essential for the intrinsic pathway of blood coagulation. A mature form of FVIII is a single-chain, 2351 amino acid polypeptide with a MW 265kDa. The FVIII can be activated by proteolytic cleavage intracellularly into a two-chain heterodimer, a heavy-chain and light-chain. The development of anti-factor VIII (FVIII) antibodies is currently one of the most serious complications in the treatment of haemophilia A patients due to the nature and properties of anti-FVIII antibodies, their mechanism of action, their neutralization by anti-idiotypic antibodies, and the role of T cells in FVIII inhibitor formation.
Synonyms AHF; DXS1253E; F8B; F8C; FVIII; HEMA
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Complement and coagulation cascades
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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