Ephrin B3 (EFNB3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant full length (1-340aa) human Ephrin-B34 protein expressed in E.coli.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	35 kDa
Gene Name	ephrin B3
Database Link	NP_001397 Entrez Gene 1949 Human UniProt ID Q15768
Background	Ehrin-B3, also known as EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. It is highly expressed in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. The ephrin ligands and receptors have been divided into two major subclasses: Ephrin-A and ephrin-B. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Synonyms	EFL6; EPLG8; LERK8
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Axon guidance

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