Legumain (LGMN) Rabbit Polyclonal Antibody
CAT#: TA354520
Rabbit anti Legumain Polyclonal Antibody
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CNY 4,675.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic peptide corresponding to the internal sequence (a portion from 100aa-190aa) of human Legumain protein. This sequence is identical to mouse, human and rat. |
Formulation | This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer. |
Purification | The Rabbit IgG is purified by Epitope Affinity Purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | ~50 kDa |
Gene Name | legumain |
Database Link | |
Background | Legumain, a 433 amino acid protein with 17 aa signal sequence, is a cystein protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic . Protein expression occurs after monocytes differentiate into dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This novel asparaginyl endopeptidase has been observed to be highly expressed in several types of tumors including colorectal cancer. |
Synonyms | AEP; LGMN1; PRSC1 |
Reference Data | |
Protein Families | Druggable Genome, Protease |
Protein Pathways | Antigen processing and presentation, Lysosome |
Documents
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