Calumenin (CALU) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the N-terminus of Calumenin protein. This sequence is identical to rat, mouse and human origins.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~48 kDa
Gene Name	calumenin
Database Link	NP_001124146 Entrez Gene 12321 MouseEntrez Gene 64366 RatEntrez Gene 813 Human UniProt ID O43852
Background	Calumenin (CALU) is a calcium binding protein localized in the endo/sarcoplasmic reticulum (ER) in mammalian tissues. It is involved ER and Golgi apparatus named CERC which is an acronym for its family members Cab-45, reticulocalbin, Erc-55 and Calumenin. The CALU gene encodes a deduced 315aa protein containing six- EF-hand Ca2+-binding protein with one potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse/rat CALU proteins are 98% identical. Two isoforms exist in cardiac and skeletal muscles, but Calumenin-2 is the main isoforms in skeletal muscle. Increasing in the expression of Calumenin in chemotherapeutic drug resistance in neoplastic cells is observed. It is also involved in the pathophysiology of thrombosis or in wound healing. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.
Synonyms	FLJ90608
Reference Data
Protein Families	Secreted Protein

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