CD4 Rabbit Polyclonal Antibody

Specifications

Product Data
Recommend Dilution	WB 0.1-1 µg/ml ELISA N/A IP 2-5 µg/ml IHC 2-10 µg/ml FC Not tested
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to internal region of human CD4 protein
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	59 kDa
Gene Name	CD4 molecule
Database Link	NP_000607 Entrez Gene 920 Human UniProt ID P01730
Background	CD4, a single-pass type I transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is an accessory protein for MHC class-II antigen/T-cell receptor interaction, and may regulate T-cell activation, induce the aggregation of lipid rafts. Upon HIV-1 binding to the cell membrane, CD4 interacts with HIV-1 envelope polyprotein gp160 and protein Vpu with presence of HIV-1 gp120.
Synonyms	CD4mut
Reference Data
Protein Families	Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transmembrane
Protein Pathways	Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.