CD14 Rabbit Polyclonal Antibody

Specifications

Product Data
Recommend Dilution	WB 0.1-1 µg/ml ELISA N/A IP N/A IHC 2-10 µg/ml FC Not tested
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein encoding aa 1-201 of human CD14
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55 kDa
Gene Name	CD14 molecule
Database Link	NP_000582 Entrez Gene 929 Human UniProt ID P08571
Background	CD14, also known lipopolysaccharide (LPS) receptor, is a 55 kDa glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein. It is expressed at high levels on monocytes and macrophage, and at lower levels on the surface of granulocytes and neutrophils. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. CD14 is anchored to cells by linkage to GPI and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 is involved in the clearance of gram-negative pathogens and in the up-regulation of adhesion molecules and cytokines expression in monocytes and neutrophils.
Synonyms	CD14 antigen; CD14 molecule; monocyte differentiation antigen CD14
Reference Data
Protein Families	Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Hematopoietic cell lineage, MAPK signaling pathway, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Toll-like receptor signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.