Sumo 2 (SUMO2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA Not tested IP 2-5 µg/ml IHC 2-10 µg/ml FC Not tested
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from C-terminus of human Sentrin-2 protein. This sequence is identical to human, mouse and rat.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	10 kDa
Gene Name	small ubiquitin-like modifier 2
Database Link	NP_001005849 Entrez Gene 6613 Human UniProt ID P61956
Background	Sentrin-2 also known as SUMO-2 is a 95-amino acids peptide that has high homologous to Sentrin-1/SUMO-1. This novel ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
Synonyms	HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3
Reference Data
Protein Families	Druggable Genome

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