Annexin IV (ANXA4) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the N-terminus of human Annexin IV. This sequence is identical to human, mouse and rat.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~34 kDa
Gene Name	annexin A4
Database Link	NP_001144 Entrez Gene 11746 MouseEntrez Gene 79124 RatEntrez Gene 307 Human UniProt ID P09525
Background	The annexins are a family of highly homologous Calcium and phospholipid binding proteins. It is composed of at least ten mammalian genes. It is characterized by a conserved core domain which binds to phospholipids in a Ca2+ dependent manner and a unique amino terminal region which may confer binding specificity. Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis/exocytosis and cellular adhesion, Annexin IV, also referred to as endonexin, functions to regulate Cl—flux by mediating calmodulin kinase II (CaMKII) activity while Annexin V has been shown to regulate PKC activity. The expressive amounts of several annexins have been shown to alter in certain pathological states such as brain ischemia and Alzheimer's disease.
Synonyms	ANX4; HEL-S-274; PIG28; ZAP36
Reference Data

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