Siglec 7 (SIGLEC7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human prostate cancer Predicted cell location: Cytoplasm or Cell membrane
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human SIGLEC7
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	sialic acid binding Ig like lectin 7
Database Link	NP_055200 Entrez Gene 27036 Human UniProt ID Q9Y286
Background	Siglec-7, which is highly expressed in monocytes and resident blood cells but not in parenchymatous cells, mediates inhibition of natural killer cell cytotoxicity. Due to alternative splicing events, two isoforms exist for Siglec-12, namely SLG-L (the long isoform) and SLG-S (the shorter isoform). These isoforms are differentially expressed with the longer isoform predominantly found in small intestine, spleen and bone marrow, and the shorter isoform predominantly found in small intestine, spleen and adrenal gland.
Synonyms	AIRM1; CD328; CDw328; D-siglec; p75; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

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