LARG (ARHGEF12) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human ARHGEF12
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Rho guanine nucleotide exchange factor 12
Database Link	NP_056128 Entrez Gene 69632 MouseEntrez Gene 23365 Human UniProt ID Q9NZN5
Background	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms	LARG; PRO2792
Reference Data
Protein Pathways	Axon guidance, Regulation of actin cytoskeleton, Vascular smooth muscle contraction

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