SIAH1 Rabbit Polyclonal Antibody
CAT#: TA350414
Rabbit Polyclonal Anti-SIAH1 Antibody
Size: 25 ul
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CNY 1,999.00
CNY 3,280.00
CNY 3,080.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | WB: 500-2000 WB positive control: LO2 cell, Mouse liver tissue, Mouse kidney tissue lysates IHC: 200-400 Positive control: Human gastric cancer Predicted cell location: Cytoplasm and Nucleus |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Full length fusion protein |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 31 kDa |
Gene Name | siah E3 ubiquitin protein ligase 1 |
Database Link | |
Background | This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. |
Synonyms | SIAH1A |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | p53 signaling pathway, Ubiquitin mediated proteolysis, Wnt signaling pathway |
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