Leukotriene A4 hydrolase (LTA4H) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Human fetal brain tissue IHC: 25-100 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm and Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human LTA4H
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	69 kDa
Gene Name	leukotriene A4 hydrolase
Database Link	NP_000886 Entrez Gene 16993 MouseEntrez Gene 299732 RatEntrez Gene 4048 Human UniProt ID P09960
Background	LTA4H (Leukotriene A4-hydrolase ) is a Zn2+-containing enzyme with both epoxide hydrolase and aminopeptidase activity. As an epoxide hydrolase, LTA4H catalyzes the hydration of LTA4 to leukotriene B4 (LTB4, 5S,12R-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid), a potent lipid chemoattractant that influences inflammation, immune responses, and host defense against infection. As an aminopeptidase, LTA4H catalyzes the cleavage of amides of para-nitroaniline. The human LTA4H gene encodes a 610 amino acid protein.
Synonyms	leukotriene A4 hydrolase
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Arachidonic acid metabolism, Metabolic pathways

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