HMGCL Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse thymus and human ovarian cancer tissue, mouse heart, human fetal liver, mouse liver tissue and SKOV3 cells IHC: 50-200 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human HMGCL
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	34 kDa
Gene Name	3-hydroxymethyl-3-methylglutaryl-CoA lyase
Database Link	NP_000182 Entrez Gene 15356 MouseEntrez Gene 79238 RatEntrez Gene 3155 Human UniProt ID P35914
Background	The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	HL
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Butanoate metabolism, Metabolic pathways, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation

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