AKIP (AURKAIP1) Rabbit Polyclonal Antibody
CAT#: TA349678S
Rabbit Polyclonal Anti-AURKAIP1 Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 500-2000 WB positive control: Human testis tissue |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Fusion protein of human AURKAIP1 |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 22 kDa |
Gene Name | aurora kinase A interacting protein 1 |
Database Link | |
Background | AKIP (AURKA-interacting protein), also known as AURKAIP1 (aurora kinase A interacting protein 1) or AIP, is a 199 amino acid protein that localizes to the nucleus and is ubiquitously expressed, with highest levels present in testis, heart and skeletal muscle. Interacting specifically with ARK-1 (aurora kinase 1), AKIP functions to induce the proteasomal-dependent degradation of ARK-1, thereby acting as a negative regulator of ARK-1 activity. AKIP is encoded by a gene which maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson?s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |
Synonyms | AIP; AKIP; MRP-S38 |
Reference Data | |
Protein Families | Druggable Genome |
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