PACS1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	PACS1 antibody was raised against a 17 amino acid peptide near the center of human PACS1.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	PACS1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 106 kDa; Observed: 105 kDa
Gene Name	phosphofurin acidic cluster sorting protein 1
Database Link	NP_060496 Entrez Gene 55690 Human UniProt ID Q6VY07
Background	The phosphofurin acidic cluster sorting protein 1 (PACS1), belongs to the PACS family of cytosolic connector proteins that localize different membrane proteins to the trans-Golgi network (TGN) (1,2). Mutations in PACS1 cause defects in cranial-neural crest migration during early development, leading to a recognizable intellectual disability syndrome (3). PACS1, along with the related protein PACS2, also plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance (4).
Synonyms	hfzo1; hfzo2
Reference Data

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