ARID1A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ARID1A antibody was raised against an 18 amino acid peptide near the amino terminus of human ARID1A.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	ARID1A antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 133, 227, 251 kDa; Observed: 130, 260 kD
Gene Name	AT-rich interaction domain 1A
Database Link	NP_006006 Entrez Gene 93760 MouseEntrez Gene 297867 RatEntrez Gene 8289 Human UniProt ID O14497
Background	The ARID1A protein is a member of the SWI/SNF family, whose members are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. ARID1A is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin (1). It possesses a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. The C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that ARID1A confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions (2).
Synonyms	B120; BAF250; BAF250a; BM029; C1orf4; ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1
Reference Data
Protein Families	Druggable Genome

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