IQSEC2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	IQSEC2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IQSEC2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	IQSEC2 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 104, 133, 141, 164 kDa; Observed: 140 kD
Gene Name	IQ motif and Sec7 domain 2
Database Link	NP_001104595 Entrez Gene 245666 MouseEntrez Gene 685244 RatEntrez Gene 23096 Human UniProt ID Q5JU85
Background	ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. Similar to the related protein IQSEC1, IQSEC2 is a guanine nucleotide exchange protein for ARF1 and ARF6 that belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1,2). IQSEC2 is a major component of the postsynaptic density (PSD) and colocalizes with PSD-95. It has been suggested to modulate the functions of the ARF proteins (1). Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation (3).
Synonyms	BRAG1; MRX1
Reference Data
Protein Pathways	Endocytosis

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