IQSEC1 Rabbit Polyclonal Antibody
CAT#: TA349112
Rabbit Polyclonal Anti-IQSEC1 Antibody
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CNY 5,808.00
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1 - 2 ug/mL |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | IQSEC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human IQSEC1 |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | IQSEC1 antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | Predicted: 106 kDa; Observed: 103 kDa |
Gene Name | IQ motif and Sec7 domain 1 |
Database Link | |
Background | ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1). As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis (2,3). IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy (4). |
Synonyms | NICE-4; NICE4 |
Reference Data |
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