Ninjurin 1 (NINJ1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC
Recommend Dilution	NINJ1 antibody can be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. Antibody validated: Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	NINJ1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human NINJ1.
Specificity	NINJ1 antibody is human, mouse and rat reactive.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	NINJ1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 17 kDa; Observed: 16 kDa
Gene Name	ninjurin 1
Database Link	NP_004139 Entrez Gene 18081 MouseEntrez Gene 25338 RatEntrez Gene 4814 Human UniProt ID Q92982
Background	Ninjurin-1 (NINJ1) is a homophilic adhesion molecule that is strongly induced in dorsal root ganglion (DRG) and Schwann cells following nerve injury and promotes neurite outgrowth of DRG neurons (1,2), suggesting that NINJ1 may play a role in nerve regeneration. NINJ1 is transcriptionally regulated by p53 and is induced by DNA damage in a p53-dependent manner. A deficiency of NINJ1 increases p53 expression, suppresses cell proliferation, but enhances apoptosis and premature senescence in a p53-dependent manner as well as radiation-induced cell mortality (3).
Synonyms	NIN1; NINJURIN
Reference Data
Protein Families	Transmembrane

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