ASCIZ (ATMIN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 2.5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ATMIN antibody was raised against a 19 amino acid peptide near the amino terminus of human ATMIN.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	ATMIN antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 73, 79, 91 kDa; Observed: 72 kDa
Gene Name	ATM interactor
Database Link	NP_056066 Entrez Gene 23300 Human UniProt ID O43313
Background	The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51 (1). ATMIN is also thought to be involved in embryonic development, as an absence of ATMIN causes late-embryonic lethality in mice with a range of organ development defects (2). It also activates the transcription DYNLL1, a light chain of the dynein motor complex and sequence-specific regulator of protein dimerization of numerous targets. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a simple dynamic feedback loop for DYNLL1 expression (3).
Synonyms	HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168
Reference Data

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