Myosin Phosphatase (PPP1R12A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat
Modifications	Phospho-specific
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Phospho-MYPT1 (Thr853) Antibody: The antiserum was produced against synthesized peptide derived from human MYPT1 around the phosphorylation site of Thr853.
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	115 kDa
Gene Name	protein phosphatase 1 regulatory subunit 12A
Database Link	NP_002471 Entrez Gene 17931 MouseEntrez Gene 116670 RatEntrez Gene 4659 Human UniProt ID O14974
Background	Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.
Synonyms	M130; MBS; MYPT1
Note	MYPT1 (Phospho-Thr853) Antibody detects endogenous levels of MYPT1 only when phosphorylated at threonine853.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Focal adhesion, Long-term potentiation, Regulation of actin cytoskeleton, Vascular smooth muscle contraction

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