PRAK (MAPKAPK5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse
Modifications	Phospho-specific
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Phospho-MAPKAPK5(Thr182) Antibody: A synthesized peptide derived from human MAPKAPK5 around the phosphorylation site of Threonine 182
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60 kDa
Gene Name	mitogen-activated protein kinase-activated protein kinase 5
Database Link	NP_003659 Entrez Gene 17165 MouseEntrez Gene 8550 Human UniProt ID Q8IW41
Background	The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms	MAPKAP-K5; MK-5; MK5; PRAK
Note	Phospho-MAPKAPK5(Thr182) Antibody detects endogenous levels of MAPKAPK5 only when phosphorylated at Threonine 182
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	MAPK signaling pathway

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