DNA polymerase alpha (POLA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-DNA Polymerase a Antibody: A synthesized peptide derived from human DNA Polymerase a
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	169 kDa
Gene Name	polymerase (DNA) alpha 1, catalytic subunit
Database Link	NP_058633 Entrez Gene 5422 Human UniProt ID P09884
Background	Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1.
Synonyms	NSX; p180; POLA
Note	DNA Polymerase a Antibody detects endogenous levels of total DNA Polymerase a
Reference Data
Protein Families	Druggable Genome
Protein Pathways	DNA replication, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

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