MRC2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-MRC2 Antibody: A synthesized peptide derived from human MRC2
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	167 kDa
Gene Name	mannose receptor C type 2
Database Link	NP_006030 Entrez Gene 17534 MouseEntrez Gene 498011 RatEntrez Gene 9902 Human UniProt ID Q9UBG0
Background	MRC2 May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover.
Synonyms	CD280; CLEC13E; ENDO180; UPARAP
Note	MRC2 Antibody detects endogenous levels of MRC2
Reference Data
Protein Families	Druggable Genome, Transmembrane

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