HRPT2 (CDC73) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ChIP (1 - 5 µg per ChIP); Western blotting (1:1,000); Immunofluorescence (12 µg per IP)
Reactivity	Human, Drosophila
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Cdc73 antibody: drosophila Cdc73 (Cell division cycle protein 73), using the full length recombinant protein.
Concentration	lot specific
Purification	Protein G purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cell division cycle 73
Database Link	NP_078805 Entrez Gene 79577 Human UniProt ID Q6P1J9
Background	Cdc73 (UniProtKB/Swiss-Prot entry Q6P1J9) s a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
Synonyms	C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX
Reference Data
Protein Families	Druggable Genome

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