SMC1 (SMC1A) Mouse Monoclonal Antibody [Clone ID: 4C5-C8-A11]

Specifications

Product Data
Clone Name	4C5-C8-A11
Applications	IF, WB
Recommend Dilution	WB: 1:1000, IF: 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for SMC1A antibody: purified recombinant human SMC1A(C-term.) protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	143 kDa
Gene Name	structural maintenance of chromosomes 1A
Database Link	NP_006297 Entrez Gene 8243 Human UniProt ID Q14683
Background	Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq, Jul 2008]
Synonyms	CDLS2; DXS423E; SB1.8; SMC1; SMC1alpha; SMC1L1; SMCB
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle, Oocyte meiosis

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