SAFB Mouse Monoclonal Antibody [Clone ID: 2E8-E2-G6]

Specifications

Product Data
Clone Name	2E8-E2-G6
Applications	IF, WB
Recommend Dilution	WB: 1:1000, IF: 1:200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for SAFB-1 antibody: purified recombinant human SAFB1 protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	130 kDa
Gene Name	scaffold attachment factor B
Database Link	NP_002958 Entrez Gene 6294 Human UniProt ID Q15424
Background	This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms	HAP; HET; SAB-B1; SAF-B; SAF-B1; SAFB1
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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