Cytochrome P450 17A1 (CYP17A1) Mouse Monoclonal Antibody [Clone ID: 6E1-H9-F6]

Specifications

Product Data
Clone Name	6E1-H9-F6
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for CYP17A1 antibody: purified recombinant human Cytochrome P450 17A1 protein fragments expressed in E.coli.
Formulation	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60 kDa
Gene Name	cytochrome P450 family 17 subfamily A member 1
Database Link	NP_000093 Entrez Gene 1586 Human UniProt ID P05093
Background	This gene encodes a member of the cytochrome P450 superfamily of enzymes.The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,steroids and other lipids.This protein localizes to the endoplasmic reticulum.It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins,mineralocorticoids,glucocorticoids,androgens,and estrogens.Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency,17-alpha-hydroxylase/17,20-lyase deficiency,pseudohermaphroditism,and adrenal hyperplasia. [provided by RefSeq,Jul 2008]
Synonyms	CPT7; CYP17; P450C17; S17AH
Reference Data
Protein Families	Druggable Genome, P450
Protein Pathways	C21-Steroid hormone metabolism, Metabolic pathways

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