CDK4 Mouse Monoclonal Antibody [Clone ID: 3F9-B12-C8]

CAT#: TA346909

Mouse Monoclonal CDK4 Antibody

Size: 20 ul 100 ul



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热销推荐

CNY 2,700.00


货期*
2周

规格
    • 100 ul

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Recombinant protein of human cyclin-dependent kinase 4 (CDK4), 20 µg
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Specifications

Product Data
Clone Name 3F9-B12-C8
Applications WB
Recommend Dilution WB: 1:1000
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen The immunogen for CDK4 antibody: purified recombinant human CDK4 protein fragments expressed in E.coli.
Formulation Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification Affinity purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 33 kDa
Gene Name cyclin-dependent kinase 4
Background The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Synonyms CMM3; PSK-J3
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer, T cell receptor signaling pathway, Tight junction
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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