Plakophilin 2 (PKP2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-PKP2 antibody: synthetic peptide directed towards the N terminal of human PKP2. Synthetic peptide located within the following region: HPLRRLEISPDSSPERAHYTHSDYQYSQRSQAGHTLHHQESRRAALLVPP
Formulation	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. Note that this product is shipped as lyophilized powder to China customers.
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	93 kDa
Gene Name	plakophilin 2
Database Link	NP_001005242 Entrez Gene 67451 MouseEntrez Gene 5318 Human UniProt ID Q99959
Background	This gene encodes a member ofThe arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments inThe cytoskeleton.This gene product may regulateThe signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity toThis locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
Synonyms	ARVD9
Note	Immunogen Sequence Homology: Human: 100%; Horse: 86%; Mouse: 86%; Dog: 79%; Rat: 77%; Bovine: 77%
Reference Data
Protein Pathways	Arrhythmogenic right ventricular cardiomyopathy (ARVC)

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