MCM10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-MCM10 antibody: synthetic peptide directed towards the middle region of human MCM10. Synthetic peptide located within the following region: PKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERV
Formulation	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. Note that this product is shipped as lyophilized powder to China customers.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	98 kDa
Gene Name	minichromosome maintenance 10 replication initiation factor
Database Link	NP_060988 Entrez Gene 55388 Human UniProt ID Q7L590
Background	The protein encoded byThis gene is one ofThe highly conserved mini-chromosome maintenance proteins (MCM) that are involved inThe initiation of eukaryotic genome replication.The hexameric protein complex formed by MCM proteins is a key component ofThe pre-replication complex (pre-RC) and it may be involved inThe formation of replication forks and inThe recruitment of other DNA replication related proteins.This protein can interact with MCM2 and MCM6, as well as withThe origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest thatThe chromatin binding ofThis protein atThe onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Synonyms	CNA43; DNA43; PRO2249
Note	Immunogen Sequence Homology: Human: 100%; Horse: 93%; Dog: 86%; Rabbit: 86%; Pig: 77%; Bovine: 77%
Reference Data
Protein Families	Stem cell - Pluripotency

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