EPS8 Mouse Monoclonal Antibody [Clone ID: 18F1F2]

CAT#: TA337153

Mouse Monoclonal Eps8 Antibody (18F1F2)



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CNY 4,897.00


货期*
5周

规格
    • 100 ug

Product images

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Recombinant protein of human epidermal growth factor receptor pathway substrate 8 (EPS8), 20 µg
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Recombinant protein of human epidermal growth factor receptor pathway substrate 8 (EPS8), 100 µg
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Specifications

Product Data
Clone Name 18F1F2
Applications IHC, WB
Recommend Dilution Immunohistochemistry, Western Blot: 1-5ug/ml, Immunohistochemistry-Paraffin: 5-7ug/ml~
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Amino acids 701-882 of human EPS8 protein were used as the immunogen for the EPS8 antibody.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name epidermal growth factor receptor pathway substrate 8
Background EPS8, an acronym for epidermal growth factor receptor pathways substrate 8, is a signaling protein and part of the molecular complex controlling actin reorganization (1, 2). EPS8 also plays an important role in innate immunity. Through LPS activation of TLR4 and the co adaptor MyD88 protein, macrophages induce enhanced EPS8 activity typified by phagocytosis- a key innate anti-microbial defense response (3). EPS8 colocalizes with TLR4 in LPS activated macrophage immunocomplexes (3). Interestingly, EPS8 also is over expressed in malignancies including breast cancers, pancreatic cancers, and colon cancers, as examples (2-4). Antibody to EPS8 provides a tool for characterizing its functional roles in motility, adhesion, signaling pathways such as non-canonical Wnt signaling and expression in normal and neoplastic cells (5).
Synonyms DFNB102
Note Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.
Reference Data
Protein Families Druggable Genome
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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