TCCR (IL27RA) Mouse Monoclonal Antibody [Clone ID: 34N4G11]

Specifications

Product Data
Clone Name	34N4G11
Applications	CyTOF-ready, FC, IHC
Recommend Dilution	Flow (Cell Surface): 1 ug/ml, Immunohistochemistry: 1:10-1:500, Flow Cytometry: 1 ug/ml, Immunohistochemistry-Paraffin: 5 ug/ml, CyTOF-ready
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A portion of amino acids 200-250 of human IL-27R (WSX-1) was used as the immunogen for this antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 27 receptor subunit alpha
Database Link	NP_004834 Entrez Gene 9466 Human UniProt ID Q6UWB1
Background	The IL-27 Receptor complex includes WSX-1 and gp130. IL-27R (WSX-1) is 65-70 kDa protein and is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes including CD4+ and CD8+ T cells, monocytes, DCs and NK cells (1-3). IL-27R activation includes STAT1, STAT3, STAT4 and STAT5, leading to differing pathway dependent effector activities. Like the IL12/IL-12R complex, the IL-27/IL-27R complex also has Th1 enhancing activity especially enhancement of IFNg production by naive T cells and NK cells (1). IL-27R mediates downregulation of Th2 activity by findings that IL-27R deficiencies mitigate inflammatory pathology in helminthic infections in mice (1, 4, 5). The possibility of utilizing IL-27R as a target for autoimmune inflammatory diseases, especially of mucosal surfaces as in human IBD, is under investigation, measured by Th2 type cytokines and bolstered through Th2
Synonyms	CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1
Reference Data
Protein Families	Druggable Genome, Transmembrane

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