TCCR (IL27RA) Mouse Monoclonal Antibody [Clone ID: 34N4G11]

CAT#: TA336909

Mouse Monoclonal IL-27 R alpha/WSX-1/TCCR Antibody (34N4G11)



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CNY 5,381.00


货期*
5周

规格
    • 100 ug

经常一起买 (4)
Transient overexpression lysate of interleukin 27 receptor, alpha (IL27RA)
    • 100 ug

CNY 3,080.00


beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

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CNY 1,430.00


Recombinant protein of human interleukin 27 receptor, alpha (IL27RA), 20 µg
    • 20 ug

CNY 2,900.00
CNY 6,650.00


Recombinant protein of human interleukin 27 receptor, alpha (IL27RA), 100 µg
    • 100 ug

CNY 9,998.00

Specifications

Product Data
Clone Name 34N4G11
Applications CyTOF-ready, FC, IHC
Recommend Dilution Flow (Cell Surface): 1 ug/ml, Immunohistochemistry: 1:10-1:500, Flow Cytometry: 1 ug/ml, Immunohistochemistry-Paraffin: 5 ug/ml, CyTOF-ready
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen A portion of amino acids 200-250 of human IL-27R (WSX-1) was used as the immunogen for this antibody.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name interleukin 27 receptor subunit alpha
Background The IL-27 Receptor complex includes WSX-1 and gp130. IL-27R (WSX-1) is 65-70 kDa protein and is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes including CD4+ and CD8+ T cells, monocytes, DCs and NK cells (1-3). IL-27R activation includes STAT1, STAT3, STAT4 and STAT5, leading to differing pathway dependent effector activities. Like the IL12/IL-12R complex, the IL-27/IL-27R complex also has Th1 enhancing activity especially enhancement of IFNg production by naive T cells and NK cells (1). IL-27R mediates downregulation of Th2 activity by findings that IL-27R deficiencies mitigate inflammatory pathology in helminthic infections in mice (1, 4, 5). The possibility of utilizing IL-27R as a target for autoimmune inflammatory diseases, especially of mucosal surfaces as in human IBD, is under investigation, measured by Th2 type cytokines and bolstered through Th2
Synonyms CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1
Reference Data
Protein Families Druggable Genome, Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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