GBP1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 2-4 ug/ml, Immunohistochemistry-Paraffin: 5 ug/ml, Immunohistochemistry: 1:10-1:500
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acids 500-550 of human GBP1 was used as the immunogen for this antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein A purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	guanylate binding protein 1
Database Link	NP_002044 Entrez Gene 2633 Human UniProt ID P32455
Background	GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules (Kunzelman, 2006). GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a (Naschberger, 2004). Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement (Naschberger, 2004). Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells (Guenzi, 2003). As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.
Synonyms	67kD; 67kDa; guanylate binding protein 1; interferon-inducible; OTTHUMP00000012352
Reference Data

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