TLR4 Rabbit Polyclonal Antibody

CAT#: TA336848

Rabbit Polyclonal TLR4 Antibody



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CNY 5,381.00


货期*
5周

规格
    • 100 ul

Product images

经常一起买 (4)
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Recombinant protein of human toll-like receptor 4 (TLR4), transcript variant 1, 20 µg
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Recombinant protein of human toll-like receptor 4 (TLR4), transcript variant 1, 100 µg
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Specifications

Product Data
Applications FC, ICC/IF, IHC, WB
Recommend Dilution Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:50, Immunohistochemistry: 1:50, Immunocytochemistry/ Immunofluorescence: 1:50, Flow Cytometry: 2 - 5 ug / million cells
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to the C-terminal portion of the human TLR4 protein (between residues 650-710) [UniProt O00206]
Formulation PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name toll like receptor 4
Background Toll like receptor 4 (TLR4) detects lipopolysaccharide of bacteria. This functionality is critical to activate the innate immune system response. HSP70 expression is enhanced when TLR4 expression is increased, resulting in an impact of the heat shock pathway in inflammation caused by infection. TLR4 binds to lipopolysaccharide and potentiates G-protein coupled receptor signaling, which then induces Neu1 expression. Cell surface expression of Neu1 and TLR4 on macrophages is critical in the ligand activation and inflammation mechanisms. Ultimately, TLR4 can be considered as one of the key elements responsible for inflammatory cytokine release and positive feedback in inflammation.
Synonyms ARMD10; CD284; TLR-4; TOLL
Note This TLR4 antibody is useful in Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and Western blot. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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