EHMT1/GLP (EHMT1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC
Recommend Dilution	IF: 1:50-1:100, IHC: 1:150, IHC-P: 1:150
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A genomic peptide made to an N-terminal region of the human EHMT1 protein (within residues 20-200). [Swiss-Prot Q9H9B1]
Formulation	PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	euchromatic histone lysine methyltransferase 1
Database Link	NP_079033 Entrez Gene 77683 MouseEntrez Gene 79813 Human UniProt ID Q9H9B1
Background	The transcription repressor EHMT1 is a histone methyltransferase that might be important in the G0/G1 cell cycle transition. In children affected with Kleefstra Syndrome, EHMT1 is mutated and seems to mis-regulate normal cellular transitions, and cause hypotonia and intellectual disability. It has been implicated in epigenetic modifications related to learning and memory formation or impairment. Finally, the translocation of this gene and erroneous protein expression have been correlated to mental retardation.
Synonyms	bA188C12.1; Eu-HMTase1; EUHMTASE1; FP13812; GLP; GLP1; KMT1D
Note	This EHMT1 antibody is useful for ICC/IF and Immunohistochemistry-paraffin sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Lysine degradation

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