Prostate Specific Antigen (KLK3) Mouse Monoclonal Antibody [Clone ID: 5A11E9]

Specifications

Product Data
Clone Name	5A11E9
Applications	ELISA, FC, IHC, WB
Recommend Dilution	Western Blot: 1:500-1:2000, Immunohistochemistry-Paraffin: 1:200-1:1000, Flow Cytometry: 1:200-1:400, ELISA: 1:10000, Immunohistochemistry: 1:10-1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Prostate Specific Antigen (amino acids 26-251) expressed in E. coli. [UniProt# P07288]
Formulation	Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	kallikrein related peptidase 3
Database Link	NP_001639 Entrez Gene 354 Human UniProt ID P07288
Background	Prostate Specific Antigen (PSA, Kallikrein-3, KLK3) is a serine protease that is usually secreted from the prostate gland and presented in seminal plasma. Prostate Specific Antigen functions in the liquefaction of seminal coagulum, through hydrolysis of the high molecular mass seminal vesicle protein. Its substrates includes semenogelin I & II, fibronectin, insulin-like growth factor binding protein 3 (IGBP3), and laminin. Highly expressed by normal and malignant prostate cancer cells, Prostate Specific Antigen has been implicated in the growth, invasion, and metastasis of prostate cancer cells. Therefore, Prostate Specific Antigen is widely used as a diagnostic marker for prostate cancer.
Synonyms	APS; hK3; KLK2A1; PSA
Note	This Prostate Specific Antigen (5A11E9) antibody is useful for Western blot, Flow Cytometry, Immunohistochemistry on paraffin-embedded sections and ELISA.
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Pathways in cancer, Prostate cancer

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