Dynamin 1 (DNM1) Mouse Monoclonal Antibody [Clone ID: 3G4B6]

Specifications

Product Data
Clone Name	3G4B6
Applications	ELISA, FC, IHC, IP, Simple Western, WB
Recommend Dilution	Immunohistochemistry-Paraffin: 1:200- 1:1000, Immunohistochemistry-Frozen: 1:200- 1:1000, ELISA: 1:10000, Immunohistochemistry: 1:10-1:500, Simple Western: 1:50, Flow Cytometry: 1 ug per million cells, Western Blot: 1:500- 1:2000, Knockout Validated, Immunoprecipitation
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human Dynamin expressed in E. coli. [UniProt# Q05193]
Formulation	Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	97 kDa
Gene Name	dynamin 1
Database Link	NP_004399 Entrez Gene 1759 Human UniProt ID Q05193
Background	Dynamin (Dynamin-1, Dyn1), with 864-amino acid protein (about 95kDa), belongs to the dynamin family. Dynamin (neuron-specific), Dynamin-2 (ubiquitously expressed), and Dynamin-3 (expressed only in the testis, brain, and lung), constitute the dynamin family. Members of the dynamin family are GPTase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C. Dynamin is a large GTPase enzyme required in membrane constriction and fission during multiple forms of endocytosis. Dynamin is also a key molecule required for the recycling of synaptic vesicles in neurons, and it has been known that Dynamin gene expression is induced during neuronal differentiation.
Synonyms	DNM
Note	This Dynamin (3G4B6) antibody is useful for Western Blot, Immunohistochemistry on paraffin-embedded sections and ELISA.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Endocytosis, Fc gamma R-mediated phagocytosis

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