TMP21 (TMED10) Rabbit Polyclonal Antibody

CAT#: TA336524

Rabbit Polyclonal Tmp21/p23 Antibody



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CNY 5,381.00


货期*
5周

规格
    • 100 ul

Product images

经常一起买 (2)
Transient overexpression lysate of transmembrane emp24-like trafficking protein 10 (yeast) (TMED10)
    • 100 ug

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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution Immunohistochemistry: 1:100-1:200, Western Blot: 2 ug/ml, Immunohistochemistry-Paraffin: 1:100-1:200, Knockdown Validated
Reactivity Human, Mouse, Rat, Bovine, Chicken, Primate, Rabbit
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to an internal sequence of the human TMP21 protein (within residues 100-200). [Swiss-Prot# P49755]
Formulation PBS, 30% glycerol, 0.1% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 21 kDa
Gene Name transmembrane p24 trafficking protein 10
Background TMP21 (transmembrane protein Tmp21) is a type I transmembrane protein with large luminal domain belonging to p24 endoplasmic reticulum/Golgi cargo family and play key roles in protein transport, membrane structure organization and secretory pathway. TMP21 is ubiquitously expressed with highest protein levels observed in pancreas and intestines. In addition to its well established role in vesicle formation and cargo transport in ER/Golgi, TMP21 has been implicated in recruitment of small GTPase ADP-ribosylation factor 1 to Golgi apparatus and ADP-ribosylation factor 1-dependent assembly of actin in the Golgi. TMP21 forms a component of presenilin complex at the plasma membranes and modulates gamma -secretase cleavage. The cytoplasmic tails of p24 family interacts with coatomer (major component of coat protein complex I or COP-I), to facilitate transport between ER and Golgi. TMP21 cycles through the early secretory pathway between intermediate and cis-Golgi compartments, and is essential for proper organization of the Golgi apparatus. TMP21 also plays an essential and non-redundant role in earliest stages of mammalian development.
Synonyms p23; P24(DELTA); p24d1; S31I125; S31III125; Tmp-21-I; TMP21
Note This TMP21 antibody is useful for Immunohistochemistry-Paraffin and Western blot analysis where a band is seen at ~21 kDa.
Reference Data
Protein Families Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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