TAPA1 (CD81) Mouse Monoclonal Antibody [Clone ID: 1D6]

Specifications

Product Data
Clone Name	1D6
Applications	CyTOF-ready, Dot, ELISA, FC, ICC/IF, IHC, IP, WB
Recommend Dilution	Western Blot: 1 - 2 ug/mL, Immunocytochemistry/ Immunofluorescence: 1:10 - 1:100, Immunoprecipitation: 1:10 - 1:500, Dot Blot, Flow Cytometry: 0.2 - 1 ug per million cells, CyTOF-ready, ELISA, Immunohistochemistry: 1:100, Immunohistochemistry-Paraffin: 1:100
Reactivity	Human, Goat, Primate, Sheep
Host	Mouse
Clonality	Monoclonal
Immunogen	Aggregated OCI-Ly8 human B cell line
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	CD81 molecule
Database Link	NP_004347 Entrez Gene 975 Human UniProt ID P60033
Background	TAPA1, also known as CD81, is found in the plasma membrane in lymphocytes and is believed to play an important role in the regulation of lymphoma cell growth. This protein is primarily found on B and T cells (lymphocytes) in humans. TAPA1 appears to be involved in a variety of cellular processes including activation, proliferation and differentiation. It is believed to act as a viral receptor for HCV and may play a crucial role in cell signaling from its place embedded in the plasma membrane. Mutations affecting CD81 can cause immunodeficiency- a disease that is characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections due to a lack of an immune response.
Synonyms	CVID6; S5.7; TAPA1; TSPAN28
Note	NB100-65805 is a potent TAPA1/CD81 reagent, it induces homotypic adhesion and has powerful anti-proliferative effects. For Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul.
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	B cell receptor signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.