PGRPS (PGLYRP1) Mouse Monoclonal Antibody [Clone ID: 188C424]

Specifications

Product Data
Clone Name	188C424
Applications	FC, ICC/IF, IHC, WB
Recommend Dilution	Western Blot: 2 ug/ml, Immunohistochemistry-Paraffin: 1:20 - 1:1000, Flow (Cell Surface), Flow (Intracellular), Immunocytochemistry/ Immunofluorescence: 1:20-1:1000, Immunohistochemistry-Frozen), Immunohistochemistry: 1:20-1:1000, Flow Cytometry: 1:20-1:2000
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was developed against KLH-conjugated synthetic peptide corresponding to amino acids 165-180 (YVLKGHRDVQRTLSPG) of human PGRP-S (NP_005082).
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	21.73 kDa
Gene Name	peptidoglycan recognition protein 1
Database Link	NP_005082 Entrez Gene 21946 MouseEntrez Gene 8993 Human UniProt ID O75594
Background	The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood. PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein. However, PGRP-S may have another, as yet unidentified function because in humans it is expressed in the bone marrow 50-100 times higher than in neutrophils.
Synonyms	PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L
Note	Flow Cytometry (Cell Surface): See Uehara et al, (2005). Immunocytochemistry/Immunofluorescence: See Dukhanina et al (2009) Immunohistochemistry (frozen): See Onkelen et al (2012)
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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