TRAF2 Mouse Monoclonal Antibody [Clone ID: 33A1293]

CAT#: TA336458

Mouse Monoclonal TRAF-2 Antibody (33A1293)



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CNY 5,381.00


货期*
5周

规格
    • 100 ug

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Recombinant protein of human TNF receptor-associated factor 2 (TRAF2), 20 µg
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Specifications

Product Data
Clone Name 33A1293
Applications IHC, WB
Recommend Dilution Western Blot: 2 ug/ml, Immunohistochemistry: 2:20-2:1000, Immunohistochemistry-Paraffin: 1:10-1:500
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Anti-TRAF2 monoclonal antibody was raised against a fusion protein corresponding to amino acids 205 to 222 of human TRAF2.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name TNF receptor associated factor 2
Background Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF2 is a 502-amino acid protein. Mutagenic studies suggest that the N-terminal RING finger and two adjacent zinc fingers of TRAF2 are required for NF-kB activation, where as interaction with TNFR is mediated through C-terminus domain. Distinct domains in the N- and -C termini are also required for association with TRAF1 and protein kinase receptor interacting protein (RIP). TRAF2 is involved in cellular resistant to TNF-induced apoptosis. TRAF-2 deficient mice appeared normal at birth, however, they die prematurely, probably due to atrophy of thymus, spleen, muscle mass and lack of TRAF-2's cytoprotective role.
Synonyms MGC:45012; TRAP; TRAP3
Note Useful in Immunohistochemistry-Paraffin See Galen et al (2008)
Reference Data
Protein Families Druggable Genome
Protein Pathways Adipocytokine signaling pathway, Apoptosis, MAPK signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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