MYD88 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 1:100, Immunohistochemistry-Paraffin: 2-5 ug/ml, Immunohistochemistry: 2-5 ug/ml, Western Blot: 0.5-2 ug/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A peptide corresponding to amino acid residues 233-248 of human MyD88.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	myeloid differentiation primary response 88
Database Link	NP_002459 Entrez Gene 17874 MouseEntrez Gene 301059 RatEntrez Gene 4615 Human UniProt ID Q99836
Background	MyD88, a protein involved in interleukin-1 (IL-1) mediated signalling was originally isolated as myeloid differentiation primary response gene (3,4). MyD88 possesses a N-terminal death domain similar to cytoplasmic segments of TNF receptor 1, Fas, and C-terminal region related to IL-1 and Toll receptors. Overexpression of MyD88 induces activation the c-Jun N-terminal kinase and NF-kB through its death domain (1,2). The C-terminus of MyD88 interacts with the IL-1 receptor and blocks NF-kB activation induced by IL-1, but not by NF-kB.
Synonyms	MYD88D
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Apoptosis, Toll-like receptor signaling pathway

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