Presenilin 2 (PSEN2) Mouse Monoclonal Antibody [Clone ID: 198C679.2.]

Specifications

Product Data
Clone Name	198C679.2.
Applications	WB
Recommend Dilution	WB: 1:250-1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was generated by immunizing mice with a synthetic peptide of human Presenilin-2 (PS-2).
Formulation	Preservative: 0.1% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Tissue culture supernatant
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	presenilin 2
Database Link	NP_036618 Entrez Gene 5664 Human UniProt ID P49810
Background	Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
Synonyms	AD3L; AD4; CMD1V; PS2; STM2
Reference Data
Protein Families	Druggable Genome, Protease, Transmembrane
Protein Pathways	Alzheimer's disease, Notch signaling pathway

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