Rb (RB1) Mouse Monoclonal Antibody [Clone ID: 172C1094]

Specifications

Product Data
Clone Name	172C1094
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen: 1:10-1:500, Immunohistochemistry: 1:10-1:500, Western Blot: 2 ug/ml, Knockdown Validated
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	RB transcriptional corepressor 1
Database Link	NP_000312 Entrez Gene 19645 MouseEntrez Gene 5925 Human UniProt ID P06400
Background	The retinoblastoma gene product (Rb) is a tumor suppressor protein and acts as cell cycle regulator. Recently, Rb has been shown to play a role in apoptosis. During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. Caspase-3 cleaves Rb into 48 and 68kDa fragments. Cleavage of Rb would make it functionally inactive, causing release of E2F-1. The E2F-1 then may promote apoptosis.
Synonyms	OSRC; p105-Rb; pp110; PPP1R130; pRb; RB
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer

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