ATF2 Mouse Monoclonal Antibody [Clone ID: 103C411.2]

Specifications

Product Data
Clone Name	103C411.2
Applications	FC, WB
Recommend Dilution	Flow Cytometry: 1:10-1:1000, Western Blot: 2 ug/ml
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was generated by immunizing mice with a synthetic peptide containing phosphorylated threonine at position 71 of human ATF-2.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	activating transcription factor 2
Database Link	NP_001243019 Entrez Gene 1386 Human UniProt ID P15336
Background	ATF-2 is a member of the group of bZip transcription factors. Heterodimer formation between members of the bZip group is common and is believed to add diversity to the cis-acting elements at which binding of the dimers is directed. Specifically, ATF-2 may dimerize with c-Jun, as occurs in response to E1a, and in so doing shift the binding preference of c-Jun toward ATF/CRE sites. Deletion analysis has indicated that the N-terminal region of ATF-2 containing threonine at residues 69 and 71 are essential for this purpose. These threonine residues are phosphorylated by JNK/SAPK for transcriptional activation.
Synonyms	CRE-BP1; CREB-2; CREB2; HB16; TREB7
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	MAPK signaling pathway

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